Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function
نویسندگان
چکیده
منابع مشابه
Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function.
BACKGROUND Hemorrhagic shock is a leading cause of death following severe trauma, and platelet transfusions are frequently necessary to achieve hemostasis. Platelets, however, require special storage conditions, and storage time has been associated with loss of platelet quality. We hypothesized that standard storage conditions have a deleterious effect on platelet mitochondrial function and pla...
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OBJECT Platelet isoprostane 8-ISO-prostaglandin F2α (8-iso-PGF2α), a proaggregating molecule, is believed to derive from nonenzymatic oxidation of arachidonic acid. We hypothesized that NADPH is implicated in isoprostane formation and platelet activation. METHODS AND RESULTS We studied 8-iso-PGF2α in platelets from 8 male patients with hereditary deficiency of gp91(phox), the catalytic subuni...
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Object—Platelet isoprostane 8-iso-PGF2 , a proaggregating molecule, is believed to derive from nonenzymatic oxidation of arachidonic acid. We hypothesized that NADPH is implicated in isoprostane formation and platelet activation. Methods and Results—We studied 8-iso-PGF2 in platelets from 8 male patients with hereditary deficiency of gp91, the catalytic subunit of NADPH oxidase, and 8 male cont...
متن کاملIncreased Platelet Reactivity Is Associated with Circulating Platelet-Monocyte Complexes and Macrophages in Human Atherosclerotic Plaques
OBJECTIVE Platelet reactivity, platelet binding to monocytes and monocyte infiltration play a detrimental role in atherosclerotic plaque progression. We investigated whether platelet reactivity was associated with levels of circulating platelet-monocyte complexes (PMCs) and macrophages in human atherosclerotic carotid plaques. METHODS Platelet reactivity was determined by measuring platelet P...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2013
ISSN: 0022-4804
DOI: 10.1016/j.jss.2013.05.097